phospholipase A2, group IVB (cytosolic)


PLA2G4B (may also be known as: None)




This gene encodes a member of the cytosolic phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of phospholipids, releasing lysophospholipids and fatty acids. This enzyme may be associated with mitochondria and early endosomes. Most tissues also express read-through transcripts from the upstream gene into this gene, some of which may encode fusion proteins combining the N-terminus of the upstream gene including its JmjC domain with the almost complete coding region of this gene, including the C2 and cytoplasmic phospholipase A2 domains. [provided by RefSeq, Jul 2008]

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006954 inflammatory response biological_process
GO:0006987 activation of signaling protein activity involved in unfolded protein response biological_process
GO:0007567 parturition biological_process
GO:0008152 metabolic process biological_process
GO:0016042 lipid catabolic process biological_process
GO:0019369 arachidonic acid metabolic process biological_process
GO:0019722 calcium-mediated signaling biological_process
GO:0030968 endoplasmic reticulum unfolded protein response biological_process
GO:0046475 glycerophospholipid catabolic process biological_process
GO:0005576 extracellular region cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005739 mitochondrion cellular_component
GO:0005768 endosome cellular_component
GO:0005829 cytosol cellular_component
GO:0016020 membrane cellular_component
GO:0031901 early endosome membrane cellular_component
GO:0031966 mitochondrial membrane cellular_component
GO:0004622 lysophospholipase activity molecular_function
GO:0005509 calcium ion binding molecular_function
GO:0005544 calcium-dependent phospholipid binding molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0047498 calcium-dependent phospholipase A2 activity molecular_function