poly (ADP-ribose) polymerase 1

Symbol

PARP1

Organism

Human

Description

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
pme-1 Caenorhabditis elegans
Parp Drosophila melanogaster
parp1 Danio rerio
Parp1 Mus musculus
Parp1 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0000723 telomere maintenance biological_process
GO:0006281 DNA repair biological_process
GO:0006284 base-excision repair biological_process
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0006366 transcription from RNA polymerase II promoter biological_process
GO:0006471 protein ADP-ribosylation biological_process
GO:0016540 protein autoprocessing biological_process
GO:0032869 cellular response to insulin stimulus biological_process
GO:0040009 regulation of growth rate biological_process
GO:0042769 DNA damage response, detection of DNA damage biological_process
GO:0070212 protein poly-ADP-ribosylation biological_process
GO:0005622 intracellular cellular_component
GO:0005634 nucleus cellular_component
GO:0005635 nuclear envelope cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005667 transcription factor complex cellular_component
GO:0005730 nucleolus cellular_component
GO:0003677 DNA binding molecular_function
GO:0003950 NAD+ ADP-ribosyltransferase activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008134 transcription factor binding molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0016757 transferase activity, transferring glycosyl groups molecular_function
GO:0046872 metal ion binding molecular_function
GO:0047485 protein N-terminus binding molecular_function
GO:0051287 NAD binding molecular_function