TAR DNA binding protein

Symbol

TARDBP (may also be known as: None)

Organism

Human

Description

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
tdp-1 Caenorhabditis elegans
CG7804 Drosophila melanogaster
tardbp Danio rerio
Tardbp Mus musculus
Tardbp Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3725 Gene expression of TARDBP increases with age Molecular skin Human TARDBP —

GO Terms

GO IDGO TermGO Category
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0006366 transcription from RNA polymerase II promoter biological_process
GO:0006397 mRNA processing biological_process
GO:0008219 cell death biological_process
GO:0008380 RNA splicing biological_process
GO:0043922 negative regulation by host of viral transcription biological_process
GO:0070935 3'-UTR-mediated mRNA stabilization biological_process
GO:0005634 nucleus cellular_component
GO:0005730 nucleolus cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0003676 nucleic acid binding molecular_function
GO:0003677 DNA binding molecular_function
GO:0003690 double-stranded DNA binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0003723 RNA binding molecular_function
GO:0003730 mRNA 3'-UTR binding molecular_function
GO:0005515 protein binding molecular_function