acyl-CoA dehydrogenase family, member 8

Symbol

ACAD8 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. The encoded protein is a mitochondrial enzyme that functions in catabolism of the branched-chain amino acid valine. Defects in this gene are the cause of isobutyryl-CoA dehydrogenase deficiency.[provided by RefSeq, Nov 2009]

Orthologs

SymbolSpecies
acdh-9 Caenorhabditis elegans
acad8 Danio rerio
Acad8 Mus musculus
Acad8 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0006629 lipid metabolic process biological_process
GO:0009083 branched chain family amino acid catabolic process biological_process
GO:0034641 cellular nitrogen compound metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0005739 mitochondrion cellular_component
GO:0005759 mitochondrial matrix cellular_component
GO:0003995 acyl-CoA dehydrogenase activity molecular_function
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors molecular_function
GO:0050660 flavin adenine dinucleotide binding molecular_function