amyloid beta (A4) precursor protein

Symbol

APP

Organism

Human

Description

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
appb Danio rerio
App Mus musculus
App Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1996 Beta-amyloid protein deposition increases Physiological brain Human APP —

GO Terms

GO IDGO TermGO Category
GO:0000085 G2 phase of mitotic cell cycle biological_process
GO:0001967 suckling behavior biological_process
GO:0002576 platelet degranulation biological_process
GO:0006378 mRNA polyadenylation biological_process
GO:0006417 regulation of translation biological_process
GO:0006468 protein phosphorylation biological_process
GO:0006878 cellular copper ion homeostasis biological_process
GO:0006897 endocytosis biological_process
GO:0006917 induction of apoptosis biological_process
GO:0007155 cell adhesion biological_process
GO:0007176 regulation of epidermal growth factor-activated receptor activity biological_process
GO:0007219 Notch signaling pathway biological_process
GO:0007409 axonogenesis biological_process
GO:0007596 blood coagulation biological_process
GO:0007617 mating behavior biological_process
GO:0007626 locomotory behavior biological_process
GO:0008088 axon cargo transport biological_process
GO:0008219 cell death biological_process
GO:0008344 adult locomotory behavior biological_process
GO:0008542 visual learning biological_process
GO:0010468 regulation of gene expression biological_process
GO:0016199 axon midline choice point recognition biological_process
GO:0016322 neuron remodeling biological_process
GO:0016358 dendrite development biological_process
GO:0030168 platelet activation biological_process
GO:0030198 extracellular matrix organization biological_process
GO:0030900 forebrain development biological_process
GO:0031175 neuron projection development biological_process
GO:0035235 ionotropic glutamate receptor signaling pathway biological_process
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway biological_process
GO:0040014 regulation of multicellular organism growth biological_process
GO:0045087 innate immune response biological_process
GO:0045665 negative regulation of neuron differentiation biological_process
GO:0045931 positive regulation of mitotic cell cycle biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0048669 collateral sprouting in absence of injury biological_process
GO:0050803 regulation of synapse structure and activity biological_process
GO:0050885 neuromuscular process controlling balance biological_process
GO:0051124 synaptic growth at neuromuscular junction biological_process
GO:0051402 neuron apoptosis biological_process
GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis biological_process
GO:0005576 extracellular region cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0005829 cytosol cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0005905 coated pit cellular_component
GO:0009986 cell surface cellular_component
GO:0016021 integral to membrane cellular_component
GO:0019717 synaptosome cellular_component
GO:0030424 axon cellular_component
GO:0031093 platelet alpha granule lumen cellular_component
GO:0031410 cytoplasmic vesicle cellular_component
GO:0031594 neuromuscular junction cellular_component
GO:0035253 ciliary rootlet cellular_component
GO:0043197 dendritic spine cellular_component
GO:0043198 dendritic shaft cellular_component
GO:0043231 intracellular membrane-bounded organelle cellular_component
GO:0045177 apical part of cell cellular_component
GO:0045202 synapse cellular_component
GO:0048471 perinuclear region of cytoplasm cellular_component
GO:0051233 spindle midzone cellular_component
GO:0003677 DNA binding molecular_function
GO:0004867 serine-type endopeptidase inhibitor activity molecular_function
GO:0005102 receptor binding molecular_function
GO:0005488 binding molecular_function
GO:0005515 protein binding molecular_function
GO:0008201 heparin binding molecular_function
GO:0016504 peptidase activator activity molecular_function
GO:0030414 peptidase inhibitor activity molecular_function
GO:0033130 acetylcholine receptor binding molecular_function
GO:0042802 identical protein binding molecular_function
GO:0046914 transition metal ion binding molecular_function
GO:0051425 PTB domain binding molecular_function