2'-5'-oligoadenylate synthetase 1, 40/46kDa

Symbol

OAS1 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006164 purine nucleotide biosynthetic process biological_process
GO:0006955 immune response biological_process
GO:0019221 cytokine-mediated signaling pathway biological_process
GO:0035457 cellular response to interferon-alpha biological_process
GO:0045071 negative regulation of viral genome replication biological_process
GO:0051259 protein oligomerization biological_process
GO:0051607 defense response to virus biological_process
GO:0060333 interferon-gamma-mediated signaling pathway biological_process
GO:0060337 type I interferon-mediated signaling pathway biological_process
GO:0060700 regulation of ribonuclease activity biological_process
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005739 mitochondrion cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005792 microsome cellular_component
GO:0005829 cytosol cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0001730 2'-5'-oligoadenylate synthetase activity molecular_function
GO:0003723 RNA binding molecular_function
GO:0003725 double-stranded RNA binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0016740 transferase activity molecular_function
GO:0016779 nucleotidyltransferase activity molecular_function