pannexin 2

Symbol

PANX2 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Orthologs

Symbol	Species
panx2	Danio rerio
Panx2	Mus musculus
Panx2	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data
DAA2351	Pannexin 2 decreases with age	Molecular	frontal lobe	Human	PANX2	8.1% Decrease Gene Expression Level
DAA2352	Pannexin 2 decreases with age	Molecular	hippocampus	Human	PANX2	19.1% Decrease Gene Expression Level
DAA2353	Pannexin 2 decreases with age	Molecular	temporal lobe	Human	PANX2	16.5% Decrease Gene Expression Level
DAA3990	Gene expression of PANX2 increases with age	Molecular	skin	Human	PANX2	—

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GO Terms

GO ID	GO Term	GO Category
GO:0006811	ion transport	biological_process
GO:0007268	synaptic transmission	biological_process
GO:0034214	protein hexamerization	biological_process
GO:0005886	plasma membrane	cellular_component
GO:0005921	gap junction	cellular_component
GO:0016021	integral to membrane	cellular_component
GO:0030054	cell junction	cellular_component
GO:0005216	ion channel activity	molecular_function
GO:0046982	protein heterodimerization activity	molecular_function
GO:0055077	gap junction hemi-channel activity	molecular_function