v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Symbol

RELA (may also be known as: None)

Organism

Human

Description

NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Orthologs

SymbolSpecies
Dif Drosophila melanogaster
rela Danio rerio
Rela Mus musculus
Rela Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2078 v-rel reticuloendotheliosis viral oncogene homolog A (avian) increases with age Molecular ovary Human RELA 60.0% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0001889 liver development biological_process
GO:0001942 hair follicle development biological_process
GO:0002224 toll-like receptor signaling pathway biological_process
GO:0002755 MyD88-dependent toll-like receptor signaling pathway biological_process
GO:0002756 MyD88-independent toll-like receptor signaling pathway biological_process
GO:0006117 acetaldehyde metabolic process biological_process
GO:0006366 transcription from RNA polymerase II promoter biological_process
GO:0006916 anti-apoptosis biological_process
GO:0006952 defense response biological_process
GO:0006954 inflammatory response biological_process
GO:0006968 cellular defense response biological_process
GO:0007568 aging biological_process
GO:0008063 Toll signaling pathway biological_process
GO:0008284 positive regulation of cell proliferation biological_process
GO:0009612 response to mechanical stimulus biological_process
GO:0009617 response to bacterium biological_process
GO:0009887 organ morphogenesis biological_process
GO:0010033 response to organic substance biological_process
GO:0010035 response to inorganic substance biological_process
GO:0010224 response to UV-B biological_process
GO:0014040 positive regulation of Schwann cell differentiation biological_process
GO:0014070 response to organic cyclic compound biological_process
GO:0019221 cytokine-mediated signaling pathway biological_process
GO:0031293 membrane protein intracellular domain proteolysis biological_process
GO:0032332 positive regulation of chondrocyte differentiation biological_process
GO:0032495 response to muramyl dipeptide biological_process
GO:0032570 response to progesterone stimulus biological_process
GO:0032868 response to insulin stimulus biological_process
GO:0033590 response to cobalamin biological_process
GO:0034097 response to cytokine stimulus biological_process
GO:0034130 toll-like receptor 1 signaling pathway biological_process
GO:0034134 toll-like receptor 2 signaling pathway biological_process
GO:0034138 toll-like receptor 3 signaling pathway biological_process
GO:0034142 toll-like receptor 4 signaling pathway biological_process
GO:0035666 TRIF-dependent toll-like receptor signaling pathway biological_process
GO:0042177 negative regulation of protein catabolic process biological_process
GO:0042493 response to drug biological_process
GO:0042542 response to hydrogen peroxide biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade biological_process
GO:0043200 response to amino acid stimulus biological_process
GO:0043278 response to morphine biological_process
GO:0044419 interspecies interaction between organisms biological_process
GO:0045084 positive regulation of interleukin-12 biosynthetic process biological_process
GO:0045087 innate immune response biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0046627 negative regulation of insulin receptor signaling pathway biological_process
GO:0048011 nerve growth factor receptor signaling pathway biological_process
GO:0050727 regulation of inflammatory response biological_process
GO:0050852 T cell receptor signaling pathway biological_process
GO:0051092 positive regulation of NF-kappaB transcription factor activity biological_process
GO:0051591 response to cAMP biological_process
GO:0051607 defense response to virus biological_process
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway biological_process
GO:0070555 response to interleukin-1 biological_process
GO:0071222 cellular response to lipopolysaccharide biological_process
GO:0071347 cellular response to interleukin-1 biological_process
GO:0071356 cellular response to tumor necrosis factor biological_process
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005667 transcription factor complex cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0043234 protein complex cellular_component
GO:0003677 DNA binding molecular_function
GO:0003682 chromatin binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0003705 sequence-specific distal enhancer binding RNA polymerase II transcription factor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008134 transcription factor binding molecular_function
GO:0019901 protein kinase binding molecular_function
GO:0031625 ubiquitin protein ligase binding molecular_function
GO:0033613 activating transcription factor binding molecular_function
GO:0042301 phosphate ion binding molecular_function
GO:0042802 identical protein binding molecular_function
GO:0043565 sequence-specific DNA binding molecular_function
GO:0044212 transcription regulatory region DNA binding molecular_function
GO:0047485 protein N-terminus binding molecular_function
GO:0051059 NF-kappaB binding molecular_function
GO:0070491 repressing transcription factor binding molecular_function
GO:0071532 ankyrin repeat binding molecular_function