complement component 5

Symbol

C5 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
c5 Danio rerio
C5 Mus musculus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2188 complement component 5 increases with age Molecular parietal lobe Human C5 35.3% Increase Gene Expression Level
DAA2199 complement component 5 increases with age Molecular frontal lobe Human C5 43.7% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0000187 activation of MAPK activity biological_process
GO:0001701 in utero embryonic development biological_process
GO:0002523 leukocyte migration involved in inflammatory response biological_process
GO:0006874 cellular calcium ion homeostasis biological_process
GO:0006917 induction of apoptosis biological_process
GO:0006935 chemotaxis biological_process
GO:0006950 response to stress biological_process
GO:0006954 inflammatory response biological_process
GO:0006956 complement activation biological_process
GO:0006957 complement activation, alternative pathway biological_process
GO:0006958 complement activation, classical pathway biological_process
GO:0007166 cell surface receptor linked signaling pathway biological_process
GO:0007186 G-protein coupled receptor signaling pathway biological_process
GO:0010575 positive regulation vascular endothelial growth factor production biological_process
GO:0010700 negative regulation of norepinephrine secretion biological_process
GO:0010760 negative regulation of macrophage chemotaxis biological_process
GO:0019835 cytolysis biological_process
GO:0033602 negative regulation of dopamine secretion biological_process
GO:0042593 glucose homeostasis biological_process
GO:0045087 innate immune response biological_process
GO:0045766 positive regulation of angiogenesis biological_process
GO:0050921 positive regulation of chemotaxis biological_process
GO:0090197 positive regulation of chemokine secretion biological_process
GO:0005576 extracellular region cellular_component
GO:0005579 membrane attack complex cellular_component
GO:0005615 extracellular space cellular_component
GO:0005625 soluble fraction cellular_component
GO:0004866 endopeptidase inhibitor activity molecular_function
GO:0005102 receptor binding molecular_function
GO:0008009 chemokine activity molecular_function
GO:0031714 C5a anaphylatoxin chemotactic receptor binding molecular_function