caspase 1, apoptosis-related cysteine peptidase

Symbol

CASP1 (may also be known as: None)

Organism

Human

Description

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]

Orthologs

SymbolSpecies
csp-1 Caenorhabditis elegans
Casp1 Mus musculus
Casp1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2248 Caspase 1, (interleukin 1, beta, convertase) increases with age Molecular frontal lobe Human CASP1 30.2% Increase Gene Expression Level
DAA2250 Caspase 1, (interleukin 1, beta, convertase) increases with age Molecular hippocampus Human CASP1 165.5% Increase Gene Expression Level
DAA2252 Caspase 1, (interleukin 1, beta, convertase) increases with age Molecular hippocampus Human CASP1 101.8% Increase Gene Expression Level
DAA2253 Caspase 1, (interleukin 1, beta, convertase) increases with age Molecular hippocampus Human CASP1 102.7% Increase Gene Expression Level
DAA2254 Caspase 1, (interleukin 1, beta, convertase) increases with age Molecular hippocampus Human CASP1 91.8% Increase Gene Expression Level
DAA2255 Caspase 1, (interleukin 1, beta, convertase) increases with age Molecular hippocampus Human CASP1 137.3% Increase Gene Expression Level
DAA2259 Caspase 1, (interleukin 1, beta, convertase) increases with age Molecular parietal lobe Human CASP1 42.0% Increase Gene Expression Level
DAA2261 Caspase 1, (interleukin 1, beta, convertase) increases with age Molecular parietal lobe Human CASP1 40.3% Increase Gene Expression Level
DAA2262 Caspase 1, (interleukin 1, beta, convertase) increases with age Molecular parietal lobe Human CASP1 28.4% Increase Gene Expression Level
DAA2263 Caspase 1, (interleukin 1, beta, convertase) increases with age Molecular parietal lobe Human CASP1 43.4% Increase Gene Expression Level
DAA2264 Caspase 1, (interleukin 1, beta, convertase) increases with age Molecular parietal lobe Human CASP1 53.3% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0006508 proteolysis biological_process
GO:0006915 apoptotic process biological_process
GO:0006919 activation of caspase activity biological_process
GO:0007165 signal transduction biological_process
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway biological_process
GO:0042981 regulation of apoptotic process biological_process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade biological_process
GO:0045087 innate immune response biological_process
GO:0071260 cellular response to mechanical stimulus biological_process
GO:0071310 cellular response to organic substance biological_process
GO:0005622 intracellular cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0004197 cysteine-type endopeptidase activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008233 peptidase activity molecular_function
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process molecular_function