| DAA988 |
Function declines |
Physiological |
dendritic cell |
Mouse |
— |
— |
|
| DAA943 |
Lower affinity antibodies generated |
Physiological |
B cell |
Mouse |
— |
— |
|
| DAA700 |
Shift in reduced:oxidized glutathione ratio in favour of oxidized gluthione |
Physiological |
blood, lymphocytes |
Mouse |
— |
— |
|
| DAA700 |
Shift in reduced:oxidized glutathione ratio in favour of oxidized gluthione |
Physiological |
blood, lymphocytes |
Mouse |
— |
— |
|
| DAA2037 |
Decrease in mitochondrial content and oxidative metabolism in cells |
Physiological |
brain |
Mouse |
— |
— |
|
| DAA2036 |
Neural stem cell pool declines |
Physiological |
hippocampus |
Mouse |
— |
— |
|
| DAA1977 |
p16 expression increases |
Molecular |
whole body |
Mouse |
Cdkn2a |
— |
|
| DAA1975 |
Loss of subcutaneous adipose skin layer |
Physiological |
skin |
Mouse |
— |
— |
|
| DAA1974 |
Bone loss |
Physiological |
bone |
Mouse |
— |
— |
|
| DAA1973 |
5-hmC increase in cerebrellum |
Molecular |
cerebellum |
Mouse |
— |
— |
|
| DAA1972 |
Glutamate-cysteine ligase (GCL) Km decrease |
Molecular |
liver |
Mouse |
Gclc |
— |
|
| DAA1971 |
Pancreatic Beta-cell replication decrease |
Physiological |
pancreas |
Mouse |
— |
— |
|
| DAA1970 |
Pdgfra (Platelete derived growth factor receptor a) mRNA levels decline |
Molecular |
pancreas |
Mouse |
Pdgfra |
— |
|
| DAA1969 |
Alox5 arachidonate 5-lipoxygenase (5-LOX) mRNA expression decrease |
Molecular |
heart |
Mouse |
Alox5 |
— |
|
| DAA1968 |
Dnmt3a mRNA expression decrease |
Molecular |
heart |
Mouse |
Dnmt3a |
— |
|
| DAA1967 |
Alox5 arachidonate 5-lipoxygenase (5-LOX) mRNA expression increase |
Molecular |
cerebellum |
Mouse |
— |
— |
|
| DAA1966 |
Alox5 arachidonate 5-lipoxygenase (5-LOX) promoter methylation increase |
Molecular |
hippocampus |
Mouse |
— |
— |
|
| DAA1965 |
Alox5 arachidonate 5-lipoxygenase (5-LOX) mRNA expression increase |
Molecular |
heart |
Mouse |
Alox5 |
— |
|
| DAA1964 |
Alox5 arachidonate 5-lipoxygenase (5-LOX) promoter methylation increase |
Molecular |
cerebellum |
Mouse |
Alox5 |
— |
|
| DAA1963 |
Alox5 arachidonate 5-lipoxygenase (5-LOX) promoter methylation increase |
Molecular |
heart |
Mouse |
Alox5 |
— |
|
| DAA1962 |
Sirt1 activity decreases |
Molecular |
bone marrow |
Mouse |
Sirt1 |
— |
|
| DAA1961 |
Intracellular NAD+ concentration decreases |
Molecular |
bone marrow |
Mouse |
— |
— |
|
| DAA1960 |
Adipocyte formation increases |
Physiological |
bone marrow |
Mouse |
— |
— |
|
| DAA1959 |
Osteoblast differentiation decreases |
Physiological |
bone marrow |
Mouse |
— |
— |
|
| DAA1954 |
Interleukin-15 levels decrease in plasma and muscle |
Physiological |
plasma, muscle |
Mouse |
— |
— |
|