| DAA859 |
Responsiveness of cholinergic receptors is decreased |
Physiological |
ileum |
Human |
— |
— |
|
| DAA861 |
Resting and squeeze pressures in anal canal decrease |
Physiological |
anus |
Human |
— |
— |
|
| DAA2594 |
Resting metabolic rate decreases with ageing |
Physiological |
whole body |
Human |
— |
— |
|
| DAA977 |
ROS production in response to stimuli unchanged |
Physiological |
neutrophil |
Human |
— |
— |
|
| DAA1981 |
Selective increase in oxidative damage and decrease in antioxidant function during aging in the substantia nigra |
Physiological |
substantia nigra |
Human |
— |
— |
|
| DAA743 |
Sensitivity of HPA axis is impaired |
Physiological |
pituitary gland, adrenal gland, hypothalamus |
Human |
— |
— |
|
| DAA743 |
Sensitivity of HPA axis is impaired |
Physiological |
pituitary gland, adrenal gland, hypothalamus |
Human |
— |
— |
|
| DAA743 |
Sensitivity of HPA axis is impaired |
Physiological |
pituitary gland, adrenal gland, hypothalamus |
Human |
— |
— |
|
| DAA1199 |
Serum klotho |
Physiological |
plasma |
Human |
KL |
Increase Hormone Level |
|
| DAA928 |
Sex hormone binding globulin levels increase |
Physiological |
plasma |
Human |
— |
— |
|
| DAA700 |
Shift in reduced:oxidized glutathione ratio in favour of oxidized gluthione |
Physiological |
blood, lymphocytes |
Mouse |
— |
— |
|
| DAA700 |
Shift in reduced:oxidized glutathione ratio in favour of oxidized gluthione |
Physiological |
blood, lymphocytes |
Mouse |
— |
— |
|
| DAA2001 |
SIRT1 activity negatively correlated with age in males |
Physiological |
skin |
Human |
SIRT1 |
— |
|
| DAA994 |
Skin thinning |
Physiological |
epidermis, dermis |
Human |
— |
— |
|
| DAA994 |
Skin thinning |
Physiological |
epidermis, dermis |
Human |
— |
— |
|
| DAA827 |
Slowing down of peristaltic motion in alimentary canal |
Physiological |
alimentary system |
Human |
— |
— |
|
| DAA898 |
Sodium conservation decreased |
Physiological |
renal tubule |
Human |
— |
— |
|
| DAA919 |
Somatostatin basal levels increase |
Physiological |
plasma |
Human |
SST |
— |
|
| DAA931 |
Sperm motility and concentration |
Physiological |
male reproductive system |
Human |
— |
— |
|
| DAA984 |
Spontaneous production of superoxide decreased |
Physiological |
neutrophil |
Human |
— |
— |
|
| DAA2053 |
Sweating capacity decreases |
Physiological |
sweat gland |
Human |
— |
— |
|
| DAA718 |
Synaptic density slightly decreases at advanced ages |
Physiological |
frontal lobe |
Human |
— |
— |
|
| DAA656 |
Synovial fluid alterations |
Physiological |
synovium |
Human |
— |
— |
|
| DAA682 |
Systolic blood pressure increases |
Physiological |
cardiovascular system |
Human |
— |
— |
|
| DAA964 |
T-cell diversity declines |
Physiological |
T cell |
Human |
— |
— |
|