| DAA998 |
Changes to elastin fibers in lower dermis |
Physiological |
dermis |
Human |
— |
— |
|
| DAA2396 |
L-pipecolic acid oxidase increases with age |
Molecular |
dermis |
Human |
PIPOX |
22.8% Increase DNA Methylation |
|
| DAA1006 |
Decreased amounts of collagen IV and VII, and abnormal elastin in dermis |
Physiological |
dermis |
Human |
— |
— |
|
| DAA994 |
Skin thinning |
Physiological |
epidermis, dermis |
Human |
— |
— |
|
| DAA1004 |
Decreased/disorganized fibril network of dermis |
Physiological |
dermis |
Human |
— |
— |
|
| DAA2413 |
Arylsulfatase G increases with age |
Molecular |
dermis |
Human |
ARSG |
19.6% Increase DNA Methylation |
|
| DAA2406 |
CD34 antigen isoform b decreases with age |
Molecular |
dermis |
Human |
CD34 |
16.6% Decrease DNA Methylation |
|
| DAA2388 |
dehydrogenase/reductase (SDR family) member 3 decreases with age |
Molecular |
dermis |
Human |
DHRS3 |
15.8% Decrease DNA Methylation |
|
| DAA995 |
Change in weave of dermis collagen fibers |
Physiological |
dermis |
Human |
— |
— |
|
| DAA2408 |
tumor necrosis factor receptor superfamily; member 17 decreases with age |
Molecular |
dermis |
Human |
TNFRSF17 |
17.6% Decrease DNA Methylation |
|
| DAA992 |
Decrease in dermal papillae density |
Physiological |
epidermis, dermis |
Human |
— |
— |
|
| DAA2417 |
tumor suppressing subtransferable candidate 5 increases with age |
Molecular |
dermis |
Human |
SLC22A18 |
16.9% Increase DNA Methylation |
|
| DAA2394 |
AMP-activated protein kinase; non-catalytic gamma-3 subunit decreases with age |
Molecular |
dermis |
Human |
PRKAG3 |
17.8% Decrease DNA Methylation |
|
| DAA2425 |
lecithin-cholesterol acyltransferase precursor decreases with age |
Molecular |
dermis |
Human |
LCAT |
18.6% Decrease DNA Methylation |
|
| DAA999 |
Microvascular alterations in arterioles, capillaries, and venules in dermis/hypodermis |
Physiological |
dermis, subcutaneous |
Human |
— |
— |
|
| DAA2415 |
engrailed homolog 1 increases with age |
Molecular |
dermis |
Human |
EN1 |
18.8% Increase DNA Methylation |
|
| DAA992 |
Decrease in dermal papillae density |
Physiological |
epidermis, dermis |
Human |
— |
— |
|
| DAA991 |
Decreased function of epithelial barriers |
Physiological |
lung, oral cavity, pharynx, oesophagus, stomach, intestine, epidermis |
Human |
— |
— |
|
| DAA1000 |
Decline in epidermis keratinocyte turnover |
Physiological |
epidermis |
Human |
— |
— |
|
| DAA994 |
Skin thinning |
Physiological |
epidermis, dermis |
Human |
— |
— |
|
| DAA993 |
Epidermis held less tightly to dermis |
Physiological |
epidermis |
Human |
— |
— |
|
| DAA1011 |
Changes in glycosaminoglycan/proteoglycan |
Physiological |
epidermis, dermis |
Human |
— |
— |
|
| DAA877 |
Higher oxidation and decreased proteasome activity |
Molecular |
epidermis |
Human |
— |
— |
|
| DAA3676 |
Gene expression of ACOT7 decreases with age |
Molecular |
skin |
Human |
ACOT7 |
— |
|
| DAA2974 |
Gene expression of ACO1 decreases with age |
Molecular |
skin |
Human |
ACO1 |
— |
|