DAA1997 |
DNA damage increases with age |
Molecular |
skin |
Human |
— |
— |
|
DAA997 |
Elastin fibers lost from upper layers of dermis |
Physiological |
dermis |
Human |
— |
— |
|
DAA993 |
Epidermis held less tightly to dermis |
Physiological |
epidermis |
Human |
— |
— |
|
DAA877 |
Higher oxidation and decreased proteasome activity |
Molecular |
epidermis |
Human |
— |
— |
|
DAA1998 |
Lipid oxidation increased with age in males |
Molecular |
skin |
Human |
— |
— |
|
DAA1002 |
Decreased ability to modulate heat loss |
Physiological |
integument system |
Human |
— |
— |
|
DAA1000 |
Decline in epidermis keratinocyte turnover |
Physiological |
epidermis |
Human |
— |
— |
|
DAA618 |
Acute rheumatic fever and chronic rheumatic heart diseases |
Pathological |
heart, skin, brain |
Human |
— |
SeriesMorbidity |
|
DAA1011 |
Changes in glycosaminoglycan/proteoglycan |
Physiological |
epidermis, dermis |
Human |
— |
— |
|
DAA598 |
Skin cancer |
Pathological |
skin |
Human |
— |
SeriesMorbidity |
|
DAA994 |
Skin thinning |
Physiological |
epidermis, dermis |
Human |
— |
— |
|
DAA994 |
Skin thinning |
Physiological |
epidermis, dermis |
Human |
— |
— |
|
DAA1011 |
Changes in glycosaminoglycan/proteoglycan |
Physiological |
epidermis, dermis |
Human |
— |
— |
|
DAA995 |
Change in weave of dermis collagen fibers |
Physiological |
dermis |
Human |
— |
— |
|
DAA998 |
Changes to elastin fibers in lower dermis |
Physiological |
dermis |
Human |
— |
— |
|
DAA2053 |
Sweating capacity decreases |
Physiological |
sweat gland |
Human |
— |
— |
|
DAA2051 |
Attenuated vasoconstriction response to cold |
Physiological |
skin |
Human |
— |
— |
|
DAA2599 |
Telomere shortening |
Physiological |
adipose tissue, skeletal muscle, skin, leukocyte |
Human |
— |
— |
|
DAA996 |
Changes to dermis collagen fiber bundles |
Physiological |
dermis |
Human |
— |
— |
|
DAA1001 |
Atrophy of hypodermal layer |
Physiological |
subcutaneous |
Human |
— |
— |
|
DAA1003 |
Wrinkles |
Physiological |
skin |
Human |
— |
— |
|
DAA1005 |
Loss of smooth padding provided by hypodermal fat cells |
Physiological |
skin |
Human |
— |
— |
|
DAA2587 |
Hair greying |
Physiological |
hair |
Human |
— |
— |
|
DAA1006 |
Decreased amounts of collagen IV and VII, and abnormal elastin in dermis |
Physiological |
dermis |
Human |
— |
— |
|
DAA2589 |
Male baldness |
Physiological |
hair |
Human |
— |
— |
|