| DAA1975 |
Loss of subcutaneous adipose skin layer |
Physiological |
skin |
Mouse |
— |
— |
|
| DAA1003 |
Wrinkles |
Physiological |
skin |
Human |
— |
— |
|
| DAA2599 |
Telomere shortening |
Physiological |
adipose tissue, skeletal muscle, skin, leukocyte |
Human |
— |
— |
|
| DAA2053 |
Sweating capacity decreases |
Physiological |
sweat gland |
Human |
— |
— |
|
| DAA994 |
Skin thinning |
Physiological |
epidermis, dermis |
Human |
— |
— |
|
| DAA994 |
Skin thinning |
Physiological |
epidermis, dermis |
Human |
— |
— |
|
| DAA2001 |
SIRT1 activity negatively correlated with age in males |
Physiological |
skin |
Human |
SIRT1 |
— |
|
| DAA999 |
Microvascular alterations in arterioles, capillaries, and venules in dermis/hypodermis |
Physiological |
dermis, subcutaneous |
Human |
— |
— |
|
| DAA999 |
Microvascular alterations in arterioles, capillaries, and venules in dermis/hypodermis |
Physiological |
dermis, subcutaneous |
Human |
— |
— |
|
| DAA2589 |
Male baldness |
Physiological |
hair |
Human |
— |
— |
|
| DAA1005 |
Loss of smooth padding provided by hypodermal fat cells |
Physiological |
skin |
Human |
— |
— |
|
| DAA2587 |
Hair greying |
Physiological |
hair |
Human |
— |
— |
|
| DAA993 |
Epidermis held less tightly to dermis |
Physiological |
epidermis |
Human |
— |
— |
|
| DAA997 |
Elastin fibers lost from upper layers of dermis |
Physiological |
dermis |
Human |
— |
— |
|
| DAA1009 |
Dermal collagen atrophies |
Physiological |
dermis |
Human |
— |
— |
|
| DAA2588 |
Depletion of hair follicle melanocytes |
Physiological |
hair follicle |
Human |
— |
— |
|
| DAA992 |
Decrease in dermal papillae density |
Physiological |
epidermis, dermis |
Human |
— |
— |
|
| DAA992 |
Decrease in dermal papillae density |
Physiological |
epidermis, dermis |
Human |
— |
— |
|
| DAA991 |
Decreased function of epithelial barriers |
Physiological |
lung, oral cavity, pharynx, oesophagus, stomach, intestine, epidermis |
Human |
— |
— |
|
| DAA1004 |
Decreased/disorganized fibril network of dermis |
Physiological |
dermis |
Human |
— |
— |
|
| DAA1006 |
Decreased amounts of collagen IV and VII, and abnormal elastin in dermis |
Physiological |
dermis |
Human |
— |
— |
|
| DAA1002 |
Decreased ability to modulate heat loss |
Physiological |
integument system |
Human |
— |
— |
|
| DAA1000 |
Decline in epidermis keratinocyte turnover |
Physiological |
epidermis |
Human |
— |
— |
|
| DAA996 |
Changes to dermis collagen fiber bundles |
Physiological |
dermis |
Human |
— |
— |
|
| DAA1011 |
Changes in glycosaminoglycan/proteoglycan |
Physiological |
epidermis, dermis |
Human |
— |
— |
|