DAA2595 |
Frequency of somatic mitochondrial mutations increases with age |
Physiological |
brain |
Human |
— |
— |
|
DAA2596 |
Frequency of mitochondrial DNA deletions increases with age |
Physiological |
brain |
Human |
— |
— |
|
DAA714 |
Neuronal soma shrinks in size |
Physiological |
brain |
Human |
— |
— |
|
DAA715 |
Lipid biosynthesis decreases |
Physiological |
central nervous system |
Human |
— |
— |
|
DAA717 |
Dendrite regression, reduction in dendrite length |
Physiological |
brain |
Human |
— |
— |
|
DAA718 |
Synaptic density slightly decreases at advanced ages |
Physiological |
frontal lobe |
Human |
— |
— |
|
DAA721 |
Neurofibrillary tangles and Lewy bodies in neurons |
Physiological |
brain |
Human |
— |
— |
|
DAA722 |
Accumulation of neuromelanin in dopaminergic nigral neurons |
Physiological |
substantia nigra |
Human |
— |
— |
|
DAA723 |
Accumulation of extracellular neuritic plaques |
Physiological |
brain |
Human |
— |
— |
|
DAA724 |
Global neuron loss |
Physiological |
cerebral cortex |
Human |
— |
— |
|
DAA725 |
Leukoaraiosis |
Physiological |
white matter |
Human |
— |
— |
|
DAA726 |
Demyelination |
Physiological |
white matter |
Human |
— |
— |
|
DAA727 |
Axon loss |
Physiological |
white matter |
Human |
— |
— |
|
DAA728 |
Brain matter volume declines |
Physiological |
brain |
Human |
— |
— |
|
DAA729 |
Gray matter volume decreases |
Physiological |
grey matter |
Human |
— |
— |
|
DAA730 |
White matter volume decreases |
Physiological |
white matter |
Human |
— |
— |
|
DAA731 |
Mean diffusivity increases and water diffusion anisotropy decreases |
Physiological |
corpus callosum, white matter |
Human |
— |
— |
|
DAA731 |
Mean diffusivity increases and water diffusion anisotropy decreases |
Physiological |
corpus callosum, white matter |
Human |
— |
— |
|
DAA732 |
Glial cell number |
Physiological |
cerebral cortex |
Human |
— |
— |
|
DAA733 |
Neurotransmitter and neuro receptor concentrations are altered |
Physiological |
brain |
Human |
— |
— |
|
DAA735 |
Localized increases and decreases in synaptic transmission |
Physiological |
brain |
Human |
— |
— |
|
DAA737 |
Permeability increases with age |
Physiological |
blood brain barrier |
Human |
— |
— |
|
DAA738 |
Cerebral spinal fluid amount increases |
Physiological |
brain |
Human |
— |
— |
|
DAA739 |
Degeneration of dopamine neurons and receptors |
Physiological |
brain |
Human |
— |
— |
|
DAA740 |
Cortical plasticity decreases |
Physiological |
brain |
Human |
— |
— |
|