DAA2596 |
Frequency of mitochondrial DNA deletions increases with age |
Physiological |
brain |
Human |
— |
— |
|
DAA2595 |
Frequency of somatic mitochondrial mutations increases with age |
Physiological |
brain |
Human |
— |
— |
|
DAA1941 |
Gait width increases |
Physiological |
nervous system |
Mouse |
— |
— |
|
DAA732 |
Glial cell number |
Physiological |
cerebral cortex |
Human |
— |
— |
|
DAA724 |
Global neuron loss |
Physiological |
cerebral cortex |
Human |
— |
— |
|
DAA729 |
Gray matter volume decreases |
Physiological |
grey matter |
Human |
— |
— |
|
DAA787 |
Increased bilateral anterior frontal activity in memory interference tests |
Physiological |
brain |
Human |
— |
— |
|
DAA786 |
Increased rhinal cortex activity and functional connectivity in tests for verbal familiarity |
Physiological |
brain |
Human |
— |
— |
|
DAA783 |
Increased sustained activity in tests of working memory |
Physiological |
brain |
Human |
— |
— |
|
DAA784 |
Increased transient activity in non-spatial auditory working memory test |
Physiological |
brain |
Human |
— |
— |
|
DAA1949 |
Intracellular glutathione content decreases |
Physiological |
brain |
Mouse |
— |
— |
|
DAA1984 |
Layer-specific dendritic regression of pyramidal cells |
Physiological |
prefrontal cortex |
Human |
— |
— |
|
DAA725 |
Leukoaraiosis |
Physiological |
white matter |
Human |
— |
— |
|
DAA715 |
Lipid biosynthesis decreases |
Physiological |
central nervous system |
Human |
— |
— |
|
DAA735 |
Localized increases and decreases in synaptic transmission |
Physiological |
brain |
Human |
— |
— |
|
DAA731 |
Mean diffusivity increases and water diffusion anisotropy decreases |
Physiological |
corpus callosum, white matter |
Human |
— |
— |
|
DAA731 |
Mean diffusivity increases and water diffusion anisotropy decreases |
Physiological |
corpus callosum, white matter |
Human |
— |
— |
|
DAA780 |
Medial temporal activation during encoding and retrieval of memory is reduced |
Physiological |
brain |
Human |
— |
— |
|
DAA1943 |
Motor coordination decreases |
Physiological |
musculoskeletal system, nervous system |
Mouse |
— |
— |
|
DAA742 |
Motor function impairment evident in altered gait and balance |
Physiological |
nervous system |
Human |
— |
— |
|
DAA2026 |
Mutations in mitochondrial DNA accumulate |
Physiological |
heart, kidney, skeletal muscle, cerebral cortex, cerebellum |
Human |
— |
— |
|
DAA2026 |
Mutations in mitochondrial DNA accumulate |
Physiological |
heart, kidney, skeletal muscle, cerebral cortex, cerebellum |
Human |
— |
— |
|
DAA2036 |
Neural stem cell pool declines |
Physiological |
hippocampus |
Mouse |
— |
— |
|
DAA721 |
Neurofibrillary tangles and Lewy bodies in neurons |
Physiological |
brain |
Human |
— |
— |
|
DAA1948 |
Neurogenesis is reduced |
Physiological |
brain |
Mouse |
— |
— |
|