DAA1948 |
Neurogenesis is reduced |
Physiological |
brain |
Mouse |
— |
— |
|
DAA2036 |
Neural stem cell pool declines |
Physiological |
hippocampus |
Mouse |
— |
— |
|
DAA1949 |
Intracellular glutathione content decreases |
Physiological |
brain |
Mouse |
— |
— |
|
DAA2037 |
Decrease in mitochondrial content and oxidative metabolism in cells |
Physiological |
brain |
Mouse |
— |
— |
|
DAA1980 |
Reaction time for a visually paced simple motor task increases with age |
Physiological |
brain |
Human |
— |
— |
|
DAA718 |
Synaptic density slightly decreases at advanced ages |
Physiological |
frontal lobe |
Human |
— |
— |
|
DAA788 |
Viscoelastic modulus of brain tissue decreases |
Physiological |
brain |
Human |
— |
— |
|
DAA2026 |
Mutations in mitochondrial DNA accumulate |
Physiological |
heart, kidney, skeletal muscle, cerebral cortex, cerebellum |
Human |
— |
— |
|
DAA785 |
Reduced hippocampal activity and functional connectivity in tests for verbal familiarity |
Physiological |
brain |
Human |
— |
— |
|
DAA960 |
Receptor expression alterations |
Physiological |
grey matter |
Human |
— |
— |
|
DAA735 |
Localized increases and decreases in synaptic transmission |
Physiological |
brain |
Human |
— |
— |
|
DAA763 |
Prolongation of calcium signals in nerve cells |
Physiological |
brain |
Human |
— |
— |
|
DAA779 |
Prefrontal cortex activation during learning is reduced |
Physiological |
brain |
Human |
— |
— |
|
DAA737 |
Permeability increases with age |
Physiological |
blood brain barrier |
Human |
— |
— |
|
DAA721 |
Neurofibrillary tangles and Lewy bodies in neurons |
Physiological |
brain |
Human |
— |
— |
|
DAA714 |
Neuronal soma shrinks in size |
Physiological |
brain |
Human |
— |
— |
|
DAA733 |
Neurotransmitter and neuro receptor concentrations are altered |
Physiological |
brain |
Human |
— |
— |
|
DAA2026 |
Mutations in mitochondrial DNA accumulate |
Physiological |
heart, kidney, skeletal muscle, cerebral cortex, cerebellum |
Human |
— |
— |
|
DAA1981 |
Selective increase in oxidative damage and decrease in antioxidant function during aging in the substantia nigra |
Physiological |
substantia nigra |
Human |
— |
— |
|
DAA780 |
Medial temporal activation during encoding and retrieval of memory is reduced |
Physiological |
brain |
Human |
— |
— |
|
DAA731 |
Mean diffusivity increases and water diffusion anisotropy decreases |
Physiological |
corpus callosum, white matter |
Human |
— |
— |
|
DAA731 |
Mean diffusivity increases and water diffusion anisotropy decreases |
Physiological |
corpus callosum, white matter |
Human |
— |
— |
|
DAA743 |
Sensitivity of HPA axis is impaired |
Physiological |
pituitary gland, adrenal gland, hypothalamus |
Human |
— |
— |
|
DAA715 |
Lipid biosynthesis decreases |
Physiological |
central nervous system |
Human |
— |
— |
|
DAA730 |
White matter volume decreases |
Physiological |
white matter |
Human |
— |
— |
|