| DAA1980 |
Reaction time for a visually paced simple motor task increases with age |
Physiological |
brain |
Human |
— |
— |
|
| DAA763 |
Prolongation of calcium signals in nerve cells |
Physiological |
brain |
Human |
— |
— |
|
| DAA779 |
Prefrontal cortex activation during learning is reduced |
Physiological |
brain |
Human |
— |
— |
|
| DAA733 |
Neurotransmitter and neuro receptor concentrations are altered |
Physiological |
brain |
Human |
— |
— |
|
| DAA714 |
Neuronal soma shrinks in size |
Physiological |
brain |
Human |
— |
— |
|
| DAA721 |
Neurofibrillary tangles and Lewy bodies in neurons |
Physiological |
brain |
Human |
— |
— |
|
| DAA780 |
Medial temporal activation during encoding and retrieval of memory is reduced |
Physiological |
brain |
Human |
— |
— |
|
| DAA735 |
Localized increases and decreases in synaptic transmission |
Physiological |
brain |
Human |
— |
— |
|
| DAA784 |
Increased transient activity in non-spatial auditory working memory test |
Physiological |
brain |
Human |
— |
— |
|
| DAA783 |
Increased sustained activity in tests of working memory |
Physiological |
brain |
Human |
— |
— |
|
| DAA724 |
Global neuron loss |
Physiological |
cerebral cortex |
Human |
— |
— |
|
| DAA2026 |
Mutations in mitochondrial DNA accumulate |
Physiological |
heart, kidney, skeletal muscle, cerebral cortex, cerebellum |
Human |
— |
— |
|
| DAA732 |
Glial cell number |
Physiological |
cerebral cortex |
Human |
— |
— |
|
| DAA718 |
Synaptic density slightly decreases at advanced ages |
Physiological |
frontal lobe |
Human |
— |
— |
|
| DAA1984 |
Layer-specific dendritic regression of pyramidal cells |
Physiological |
prefrontal cortex |
Human |
— |
— |
|
| DAA2036 |
Neural stem cell pool declines |
Physiological |
hippocampus |
Mouse |
— |
— |
|
| DAA743 |
Sensitivity of HPA axis is impaired |
Physiological |
pituitary gland, adrenal gland, hypothalamus |
Human |
— |
— |
|
| DAA722 |
Accumulation of neuromelanin in dopaminergic nigral neurons |
Physiological |
substantia nigra |
Human |
— |
— |
|
| DAA1981 |
Selective increase in oxidative damage and decrease in antioxidant function during aging in the substantia nigra |
Physiological |
substantia nigra |
Human |
— |
— |
|
| DAA2026 |
Mutations in mitochondrial DNA accumulate |
Physiological |
heart, kidney, skeletal muscle, cerebral cortex, cerebellum |
Human |
— |
— |
|
| DAA731 |
Mean diffusivity increases and water diffusion anisotropy decreases |
Physiological |
corpus callosum, white matter |
Human |
— |
— |
|
| DAA731 |
Mean diffusivity increases and water diffusion anisotropy decreases |
Physiological |
corpus callosum, white matter |
Human |
— |
— |
|
| DAA725 |
Leukoaraiosis |
Physiological |
white matter |
Human |
— |
— |
|
| DAA726 |
Demyelination |
Physiological |
white matter |
Human |
— |
— |
|
| DAA727 |
Axon loss |
Physiological |
white matter |
Human |
— |
— |
|