| DAA1953 |
Interleukin-6 plasma levels are elevated in response to acute systemic inflammation |
Physiological |
immune system |
Mouse |
— |
— |
|
| DAA943 |
Lower affinity antibodies generated |
Physiological |
B cell |
Mouse |
— |
— |
|
| DAA700 |
Shift in reduced:oxidized glutathione ratio in favour of oxidized gluthione |
Physiological |
blood, lymphocytes |
Mouse |
— |
— |
|
| DAA988 |
Function declines |
Physiological |
dendritic cell |
Mouse |
— |
— |
|
| DAA1947 |
Vitamin C levels decrease |
Physiological |
blood, T cell |
Mouse |
— |
— |
|
| DAA968 |
Chronic inflammation increases |
Physiological |
blood, immune system |
Human |
— |
— |
|
| DAA974 |
Chemotaxis is reduced |
Physiological |
neutrophil, dendritic cell |
Human |
— |
— |
|
| DAA972 |
Chemotaxis and adhesion activity unchanged in vitro |
Physiological |
neutrophil |
Human |
— |
— |
|
| DAA1231 |
decreased NF-KappaB induction in T cells |
Molecular |
T cell |
Human |
— |
— |
|
| DAA1229 |
Declining T-lymphocyte production in the thymus |
Physiological |
thymus |
Human |
— |
— |
|
| DAA1232 |
decreased proteasomal activity in T cells |
Molecular |
T cell |
Human |
— |
— |
|
| DAA983 |
Diminished superoxide production in response to Fc |
Physiological |
neutrophil |
Human |
— |
— |
|
| DAA1230 |
E-rosette-forming cells decrease |
Physiological |
thymus |
Human |
— |
— |
|
| DAA965 |
Incidence of anergia increases |
Physiological |
immune system |
Human |
— |
— |
|
| DAA974 |
Chemotaxis is reduced |
Physiological |
neutrophil, dendritic cell |
Human |
— |
— |
|
| DAA952 |
Fewer CD4+ and CD8+ cells |
Physiological |
T cell |
Human |
— |
— |
|
| DAA2034 |
Expression of WRN decreases |
Molecular |
blood, immune system |
Human |
WRN |
52.0% Decrease Gene Expression Level |
|
| DAA986 |
Cytotoxicity and interleukin-2 response of natural killer cells decreases |
Physiological |
natural killer cell |
Human |
— |
— |
|
| DAA985 |
Functional decline and decreases in macrophage numbers in bone marrow |
Physiological |
macrophage |
Human |
— |
— |
|
| DAA961 |
Increased apoptosis associated with Fas and Fas-ligand expression |
Physiological |
T cell |
Human |
FAS |
— |
|
| DAA2581 |
Level of miR-101 decreases with age |
Molecular |
T cell |
Human |
MIR101-1 |
49.5% Decrease miRNA Level |
|
| DAA2575 |
Level of miR-106b decreases with age |
Molecular |
T cell |
Human |
MIR106B |
40.4% Decrease miRNA Level |
|
| DAA962 |
Interleukin-2 production in response to influenza vaccine declines |
Physiological |
T cell |
Human |
IL2 |
— |
|
| DAA982 |
expression of CD16 receptor diminished |
Molecular |
neutrophil |
Human |
FCGR3A |
— |
|
| DAA963 |
Expansion into effector cells is reduced |
Physiological |
naïve T cell |
Human |
— |
— |
|