DAA2578 |
Level of miR-15b decreases with age |
Molecular |
T cell |
Human |
MIR15B |
29.4% Decrease miRNA Level |
|
DAA2551 |
Level of miR-17 decreases with age |
Molecular |
T cell |
Human |
MIR17 |
63.1% Decrease miRNA Level |
|
DAA2580 |
Level of miR-18b decreases with age |
Molecular |
T cell |
Human |
MIR18B |
39.3% Decrease miRNA Level |
|
DAA2563 |
Level of miR-19a decreases with age |
Molecular |
T cell |
Human |
MIR19A |
49.0% Decrease miRNA Level |
|
DAA2548 |
Level of miR-19b decreases with age |
Molecular |
T cell |
Human |
MIR19B1 |
63.5% Decrease miRNA Level |
|
DAA949 |
Cytomegalovirus infection incidence increases |
Pathological |
immune system |
Human |
— |
— |
|
DAA972 |
Chemotaxis and adhesion activity unchanged in vitro |
Physiological |
neutrophil |
Human |
— |
— |
|
DAA973 |
Chemotaxis and respiratory burst capacity in response to GM-CSF priming decreased |
Physiological |
neutrophil |
Human |
— |
— |
|
DAA974 |
Chemotaxis is reduced |
Physiological |
neutrophil, dendritic cell |
Human |
— |
— |
|
DAA974 |
Chemotaxis is reduced |
Physiological |
neutrophil, dendritic cell |
Human |
— |
— |
|
DAA968 |
Chronic inflammation increases |
Physiological |
blood, immune system |
Human |
— |
— |
|
DAA986 |
Cytotoxicity and interleukin-2 response of natural killer cells decreases |
Physiological |
natural killer cell |
Human |
— |
— |
|
DAA1229 |
Declining T-lymphocyte production in the thymus |
Physiological |
thymus |
Human |
— |
— |
|
DAA935 |
Pro-B cell generation and differentiation declines |
Physiological |
bone marrow, B cell |
Human |
— |
— |
|
DAA956 |
Proliferation is reduced |
Physiological |
lymphocytes |
Human |
— |
— |
|
DAA983 |
Diminished superoxide production in response to Fc |
Physiological |
neutrophil |
Human |
— |
— |
|
DAA1230 |
E-rosette-forming cells decrease |
Physiological |
thymus |
Human |
— |
— |
|
DAA965 |
Incidence of anergia increases |
Physiological |
immune system |
Human |
— |
— |
|
DAA963 |
Expansion into effector cells is reduced |
Physiological |
naïve T cell |
Human |
— |
— |
|
DAA977 |
ROS production in response to stimuli unchanged |
Physiological |
neutrophil |
Human |
— |
— |
|
DAA984 |
Spontaneous production of superoxide decreased |
Physiological |
neutrophil |
Human |
— |
— |
|
DAA952 |
Fewer CD4+ and CD8+ cells |
Physiological |
T cell |
Human |
— |
— |
|
DAA985 |
Functional decline and decreases in macrophage numbers in bone marrow |
Physiological |
macrophage |
Human |
— |
— |
|
DAA961 |
Increased apoptosis associated with Fas and Fas-ligand expression |
Physiological |
T cell |
Human |
FAS |
— |
|
DAA964 |
T-cell diversity declines |
Physiological |
T cell |
Human |
— |
— |
|