| DAA1947 |
Vitamin C levels decrease |
Physiological |
blood, T cell |
Mouse |
— |
— |
|
| DAA700 |
Shift in reduced:oxidized glutathione ratio in favour of oxidized gluthione |
Physiological |
blood, lymphocytes |
Mouse |
— |
— |
|
| DAA943 |
Lower affinity antibodies generated |
Physiological |
B cell |
Mouse |
— |
— |
|
| DAA1953 |
Interleukin-6 plasma levels are elevated in response to acute systemic inflammation |
Physiological |
immune system |
Mouse |
— |
— |
|
| DAA988 |
Function declines |
Physiological |
dendritic cell |
Mouse |
— |
— |
|
| DAA948 |
Volume of perivascular space around thymus increases |
Physiological |
thymus |
Human |
— |
— |
|
| DAA966 |
Vaccination antibody response is impaired |
Physiological |
immune system |
Human |
— |
— |
|
| DAA945 |
Thymus involution |
Physiological |
thymus |
Human |
— |
— |
|
| DAA2599 |
Telomere shortening |
Physiological |
adipose tissue, skeletal muscle, skin, leukocyte |
Human |
— |
— |
|
| DAA964 |
T-cell diversity declines |
Physiological |
T cell |
Human |
— |
— |
|
| DAA984 |
Spontaneous production of superoxide decreased |
Physiological |
neutrophil |
Human |
— |
— |
|
| DAA977 |
ROS production in response to stimuli unchanged |
Physiological |
neutrophil |
Human |
— |
— |
|
| DAA956 |
Proliferation is reduced |
Physiological |
lymphocytes |
Human |
— |
— |
|
| DAA935 |
Pro-B cell generation and differentiation declines |
Physiological |
bone marrow, B cell |
Human |
— |
— |
|
| DAA981 |
Phagocytosis activity unchanged in response to unopsonized targets |
Physiological |
neutrophil |
Human |
— |
— |
|
| DAA980 |
Phagocytosis activity decreased in response to opsonized targets |
Physiological |
neutrophil |
Human |
— |
— |
|
| DAA954 |
Number of T cell progenitors declines |
Physiological |
T cell progenitor |
Human |
— |
— |
|
| DAA934 |
Number of mature B cells leaving the bone marrow declines |
Physiological |
bone marrow, B cell |
Human |
— |
— |
|
| DAA939 |
Naive cell number increases and memory cells decrease |
Physiological |
B cell |
Human |
— |
— |
|
| DAA944 |
Less antibodies generated |
Physiological |
B cell |
Human |
— |
— |
|
| DAA955 |
Interleukin-7 production declines |
Physiological |
stromal cell |
Human |
IL7 |
— |
|
| DAA975 |
Infiltration at injury site is reduced |
Physiological |
neutrophil |
Human |
— |
— |
|
| DAA987 |
Increase in total number of cells |
Physiological |
natural killer cell |
Human |
— |
— |
|
| DAA953 |
Increase in cells that are both CD8+ and CD28-null |
Physiological |
T regulatory cell |
Human |
— |
— |
|
| DAA950 |
Immune response to Epstein-Barr virus decreases in cytomegalovirus positive individuals |
Physiological |
immune system |
Human |
— |
— |
|