DAA989 |
telomere shortening |
Molecular |
lymphocytes |
Human |
— |
— |
|
DAA988 |
Function declines |
Physiological |
dendritic cell |
Mouse |
— |
— |
|
DAA987 |
Increase in total number of cells |
Physiological |
natural killer cell |
Human |
— |
— |
|
DAA986 |
Cytotoxicity and interleukin-2 response of natural killer cells decreases |
Physiological |
natural killer cell |
Human |
— |
— |
|
DAA985 |
Functional decline and decreases in macrophage numbers in bone marrow |
Physiological |
macrophage |
Human |
— |
— |
|
DAA984 |
Spontaneous production of superoxide decreased |
Physiological |
neutrophil |
Human |
— |
— |
|
DAA983 |
Diminished superoxide production in response to Fc |
Physiological |
neutrophil |
Human |
— |
— |
|
DAA982 |
expression of CD16 receptor diminished |
Molecular |
neutrophil |
Human |
FCGR3A |
— |
|
DAA981 |
Phagocytosis activity unchanged in response to unopsonized targets |
Physiological |
neutrophil |
Human |
— |
— |
|
DAA980 |
Phagocytosis activity decreased in response to opsonized targets |
Physiological |
neutrophil |
Human |
— |
— |
|
DAA979 |
Apoptotic pathway in response to stimuli disrupted |
Physiological |
neutrophil |
Human |
— |
— |
|
DAA977 |
ROS production in response to stimuli unchanged |
Physiological |
neutrophil |
Human |
— |
— |
|
DAA975 |
Infiltration at injury site is reduced |
Physiological |
neutrophil |
Human |
— |
— |
|
DAA974 |
Chemotaxis is reduced |
Physiological |
neutrophil, dendritic cell |
Human |
— |
— |
|
DAA974 |
Chemotaxis is reduced |
Physiological |
neutrophil, dendritic cell |
Human |
— |
— |
|
DAA973 |
Chemotaxis and respiratory burst capacity in response to GM-CSF priming decreased |
Physiological |
neutrophil |
Human |
— |
— |
|
DAA972 |
Chemotaxis and adhesion activity unchanged in vitro |
Physiological |
neutrophil |
Human |
— |
— |
|
DAA968 |
Chronic inflammation increases |
Physiological |
blood, immune system |
Human |
— |
— |
|
DAA966 |
Vaccination antibody response is impaired |
Physiological |
immune system |
Human |
— |
— |
|
DAA965 |
Incidence of anergia increases |
Physiological |
immune system |
Human |
— |
— |
|
DAA964 |
T-cell diversity declines |
Physiological |
T cell |
Human |
— |
— |
|
DAA963 |
Expansion into effector cells is reduced |
Physiological |
naïve T cell |
Human |
— |
— |
|
DAA962 |
Interleukin-2 production in response to influenza vaccine declines |
Physiological |
T cell |
Human |
IL2 |
— |
|
DAA961 |
Increased apoptosis associated with Fas and Fas-ligand expression |
Physiological |
T cell |
Human |
FAS |
— |
|
DAA959 |
telomere shortening |
Molecular |
naïve T cell |
Human |
— |
— |
|