DAA757 |
Parkinsonian signs |
— |
nervous system |
Human |
|
DAA1941 |
Gait width increases |
— |
nervous system |
Mouse |
|
DAA1943 |
Motor coordination decreases |
— |
musculoskeletal system, nervous system |
Mouse |
|
DAA715 |
Lipid biosynthesis decreases |
— |
central nervous system |
Human |
|
DAA779 |
Prefrontal cortex activation during learning is reduced |
— |
brain |
Human |
|
DAA2596 |
Frequency of mitochondrial DNA deletions increases with age |
— |
brain |
Human |
|
DAA714 |
Neuronal soma shrinks in size |
— |
brain |
Human |
|
DAA721 |
Neurofibrillary tangles and Lewy bodies in neurons |
— |
brain |
Human |
|
DAA1948 |
Neurogenesis is reduced |
— |
brain |
Mouse |
|
DAA780 |
Medial temporal activation during encoding and retrieval of memory is reduced |
— |
brain |
Human |
|
DAA735 |
Localized increases and decreases in synaptic transmission |
— |
brain |
Human |
|
DAA1949 |
Intracellular glutathione content decreases |
— |
brain |
Mouse |
|
DAA1996 |
Beta-amyloid protein deposition increases |
— |
brain |
Human |
|
DAA723 |
Accumulation of extracellular neuritic plaques |
— |
brain |
Human |
|
DAA784 |
Increased transient activity in non-spatial auditory working memory test |
— |
brain |
Human |
|
DAA783 |
Increased sustained activity in tests of working memory |
— |
brain |
Human |
|
DAA786 |
Increased rhinal cortex activity and functional connectivity in tests for verbal familiarity |
— |
brain |
Human |
|
DAA787 |
Increased bilateral anterior frontal activity in memory interference tests |
— |
brain |
Human |
|
DAA728 |
Brain matter volume declines |
— |
brain |
Human |
|
DAA2037 |
Decrease in mitochondrial content and oxidative metabolism in cells |
— |
brain |
Mouse |
|
DAA1217 |
Brain volume decrease |
— |
brain |
Human |
|
DAA1993 |
Brain volume decreases in a regional-specific way |
— |
brain |
Human |
|
DAA765 |
Calcium binding capacity decreases in neurons |
— |
brain |
Human |
|
DAA2595 |
Frequency of somatic mitochondrial mutations increases with age |
— |
brain |
Human |
|
DAA741 |
Cerebral blood flow and glucose utilization are reduced |
— |
brain |
Human |
|