cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
Symbol
CSTF3
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| suf-1 | Caenorhabditis elegans | |
| su(f) | Drosophila melanogaster | |
| cstf3 | Danio rerio | |
| Cstf3 | Mus musculus | |
| Cstf3 | Rattus norvegicus | |
| rna14 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0000398 | nuclear mRNA splicing, via spliceosome | biological_process | |
| GO:0006366 | transcription from RNA polymerase II promoter | biological_process | |
| GO:0006369 | termination of RNA polymerase II transcription | biological_process | |
| GO:0006378 | mRNA polyadenylation | biological_process | |
| GO:0006379 | mRNA cleavage | biological_process | |
| GO:0006396 | RNA processing | biological_process | |
| GO:0006397 | mRNA processing | biological_process | |
| GO:0008380 | RNA splicing | biological_process | |
| GO:0010467 | gene expression | biological_process | |
| GO:0031124 | mRNA 3'-end processing | biological_process | |
| GO:0005622 | intracellular | cellular_component | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005654 | nucleoplasm | cellular_component | |
| GO:0005730 | nucleolus | cellular_component | |
| GO:0003723 | RNA binding | molecular_function | |
| GO:0005488 | binding | molecular_function | |