interleukin 1, beta

Symbol

IL1B (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
il1b Danio rerio
Il1b Mus musculus
Il1b Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3203 Gene expression of IL1B decreases with age Molecular skin Human IL1B —

GO Terms

GO IDGO TermGO Category
GO:0000165 MAPKKK cascade biological_process
GO:0000187 activation of MAPK activity biological_process
GO:0001666 response to hypoxia biological_process
GO:0001934 positive regulation of protein phosphorylation biological_process
GO:0002439 chronic inflammatory response to antigenic stimulus biological_process
GO:0002711 positive regulation of T cell mediated immunity biological_process
GO:0006915 apoptotic process biological_process
GO:0006916 anti-apoptosis biological_process
GO:0006954 inflammatory response biological_process
GO:0006955 immune response biological_process
GO:0007165 signal transduction biological_process
GO:0007204 elevation of cytosolic calcium ion concentration biological_process
GO:0007267 cell-cell signaling biological_process
GO:0007566 embryo implantation biological_process
GO:0007568 aging biological_process
GO:0007584 response to nutrient biological_process
GO:0007613 memory biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0009408 response to heat biological_process
GO:0010193 response to ozone biological_process
GO:0010243 response to organic nitrogen biological_process
GO:0010332 response to gamma radiation biological_process
GO:0010575 positive regulation vascular endothelial growth factor production biological_process
GO:0010628 positive regulation of gene expression biological_process
GO:0010829 negative regulation of glucose transport biological_process
GO:0014050 negative regulation of glutamate secretion biological_process
GO:0014070 response to organic cyclic compound biological_process
GO:0014805 smooth muscle adaptation biological_process
GO:0019221 cytokine-mediated signaling pathway biological_process
GO:0030593 neutrophil chemotaxis biological_process
GO:0030728 ovulation biological_process
GO:0030730 sequestering of triglyceride biological_process
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway biological_process
GO:0031622 positive regulation of fever generation biological_process
GO:0031663 lipopolysaccharide-mediated signaling pathway biological_process
GO:0032308 positive regulation of prostaglandin secretion biological_process
GO:0032355 response to estradiol stimulus biological_process
GO:0032496 response to lipopolysaccharide biological_process
GO:0032611 interleukin-1 beta production biological_process
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production biological_process
GO:0032729 positive regulation of interferon-gamma production biological_process
GO:0032755 positive regulation of interleukin-6 production biological_process
GO:0032757 positive regulation of interleukin-8 production biological_process
GO:0033129 positive regulation of histone phosphorylation biological_process
GO:0033198 response to ATP biological_process
GO:0033280 response to vitamin D biological_process
GO:0033591 response to L-ascorbic acid biological_process
GO:0034116 positive regulation of heterotypic cell-cell adhesion biological_process
GO:0035066 positive regulation of histone acetylation biological_process
GO:0035176 social behavior biological_process
GO:0035505 positive regulation of myosin light chain kinase activity biological_process
GO:0035690 cellular response to drug biological_process
GO:0042060 wound healing biological_process
GO:0042102 positive regulation of T cell proliferation biological_process
GO:0042346 positive regulation of NF-kappaB import into nucleus biological_process
GO:0042493 response to drug biological_process
GO:0043065 positive regulation of apoptotic process biological_process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB cascade biological_process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade biological_process
GO:0043278 response to morphine biological_process
GO:0043407 negative regulation of MAP kinase activity biological_process
GO:0043491 protein kinase B signaling cascade biological_process
GO:0043507 positive regulation of JUN kinase activity biological_process
GO:0045080 positive regulation of chemokine biosynthetic process biological_process
GO:0045086 positive regulation of interleukin-2 biosynthetic process biological_process
GO:0045410 positive regulation of interleukin-6 biosynthetic process biological_process
GO:0045429 positive regulation of nitric oxide biosynthetic process biological_process
GO:0045766 positive regulation of angiogenesis biological_process
GO:0045833 negative regulation of lipid metabolic process biological_process
GO:0045840 positive regulation of mitosis biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0046330 positive regulation of JNK cascade biological_process
GO:0046627 negative regulation of insulin receptor signaling pathway biological_process
GO:0046827 positive regulation of protein export from nucleus biological_process
GO:0050796 regulation of insulin secretion biological_process
GO:0050900 leukocyte migration biological_process
GO:0050995 negative regulation of lipid catabolic process biological_process
GO:0050996 positive regulation of lipid catabolic process biological_process
GO:0051044 positive regulation of membrane protein ectodomain proteolysis biological_process
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity biological_process
GO:0051092 positive regulation of NF-kappaB transcription factor activity biological_process
GO:0051384 response to glucocorticoid stimulus biological_process
GO:0051781 positive regulation of cell division biological_process
GO:0060355 positive regulation of cell adhesion molecule production biological_process
GO:0060559 positive regulation of calcidiol 1-monooxygenase activity biological_process
GO:0070164 negative regulation of adiponectin secretion biological_process
GO:0070374 positive regulation of ERK1 and ERK2 cascade biological_process
GO:0071260 cellular response to mechanical stimulus biological_process
GO:0071310 cellular response to organic substance biological_process
GO:0071407 cellular response to organic cyclic compound biological_process
GO:0071639 positive regulation of monocyte chemotactic protein-1 production biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005829 cytosol cellular_component
GO:0030141 secretory granule cellular_component
GO:0031982 vesicle cellular_component
GO:0005125 cytokine activity molecular_function
GO:0005149 interleukin-1 receptor binding molecular_function
GO:0008083 growth factor activity molecular_function
GO:0019904 protein domain specific binding molecular_function