interleukin 7






The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]


Il7 Mus musculus
Il7 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0002360 T cell lineage commitment biological_process
GO:0006916 anti-apoptosis biological_process
GO:0006955 immune response biological_process
GO:0006959 humoral immune response biological_process
GO:0007267 cell-cell signaling biological_process
GO:0008284 positive regulation of cell proliferation biological_process
GO:0009887 organ morphogenesis biological_process
GO:0010468 regulation of gene expression biological_process
GO:0030308 negative regulation of cell growth biological_process
GO:0030890 positive regulation of B cell proliferation biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0043086 negative regulation of catalytic activity biological_process
GO:0045453 bone resorption biological_process
GO:0045582 positive regulation of T cell differentiation biological_process
GO:0046622 positive regulation of organ growth biological_process
GO:0048873 homeostasis of number of cells within a tissue biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005125 cytokine activity molecular_function
GO:0005126 cytokine receptor binding molecular_function
GO:0005139 interleukin-7 receptor binding molecular_function
GO:0005515 protein binding molecular_function
GO:0008083 growth factor activity molecular_function