luteinizing hormone/choriogonadotropin receptor

Symbol

LHCGR (may also be known as: None)

Organism

Human

Description

This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
lhcgr Danio rerio
Lhcgr Mus musculus
Lhcgr Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2810 Gene expression of LHCGR increases with age Molecular adipose tissue Human LHCGR —

GO Terms

GO IDGO TermGO Category
GO:0001541 ovarian follicle development biological_process
GO:0006622 protein targeting to lysosome biological_process
GO:0007186 G-protein coupled receptor signaling pathway biological_process
GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger biological_process
GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger biological_process
GO:0007190 activation of adenylate cyclase activity biological_process
GO:0007200 activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger biological_process
GO:0007283 spermatogenesis biological_process
GO:0007417 central nervous system development biological_process
GO:0008584 male gonad development biological_process
GO:0009755 hormone-mediated signaling pathway biological_process
GO:0030539 male genitalia development biological_process
GO:0042493 response to drug biological_process
GO:0046544 development of secondary male sexual characteristics biological_process
GO:0046886 positive regulation of hormone biosynthetic process biological_process
GO:0050482 arachidonic acid secretion biological_process
GO:0050850 positive regulation of calcium-mediated signaling biological_process
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol biological_process
GO:0060065 uterus development biological_process
GO:0072520 seminiferous tubule development biological_process
GO:0090030 regulation of steroid hormone biosynthetic process biological_process
GO:0005615 extracellular space cellular_component
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005764 lysosome cellular_component
GO:0005768 endosome cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0031233 intrinsic to external side of plasma membrane cellular_component
GO:0043235 receptor complex cellular_component
GO:0004871 signal transducer activity molecular_function
GO:0004872 receptor activity molecular_function
GO:0004964 luteinizing hormone receptor activity molecular_function
GO:0008528 G-protein coupled peptide receptor activity molecular_function
GO:0017046 peptide hormone binding molecular_function
GO:0035472 choriogonadotropin hormone receptor activity molecular_function
GO:0042803 protein homodimerization activity molecular_function
GO:0051117 ATPase binding molecular_function