CD4 molecule

Symbol

CD4 (may also be known as: None)

Organism

Human

Description

This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]

Orthologs

SymbolSpecies
Cd4 Mus musculus
Cd4 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2654 Hypomethylation of CD4 is positively correlated with age Molecular blood Human CD4 —

GO Terms

GO IDGO TermGO Category
GO:0001816 cytokine production biological_process
GO:0006948 induction by virus of host cell-cell fusion biological_process
GO:0006955 immune response biological_process
GO:0007155 cell adhesion biological_process
GO:0007165 signal transduction biological_process
GO:0007166 cell surface receptor linked signaling pathway biological_process
GO:0007167 enzyme linked receptor protein signaling pathway biological_process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway biological_process
GO:0016032 viral reproduction biological_process
GO:0019059 initiation of viral infection biological_process
GO:0030217 T cell differentiation biological_process
GO:0030260 entry into host cell biological_process
GO:0031295 T cell costimulation biological_process
GO:0032507 maintenance of protein location in cell biological_process
GO:0044419 interspecies interaction between organisms biological_process
GO:0045058 T cell selection biological_process
GO:0045086 positive regulation of interleukin-2 biosynthetic process biological_process
GO:0045087 innate immune response biological_process
GO:0045234 protein palmitoleylation biological_process
GO:0045860 positive regulation of protein kinase activity biological_process
GO:0050690 regulation of defense response to virus by virus biological_process
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation biological_process
GO:0050850 positive regulation of calcium-mediated signaling biological_process
GO:0050852 T cell receptor signaling pathway biological_process
GO:0050863 regulation of T cell activation biological_process
GO:0050870 positive regulation of T cell activation biological_process
GO:0005769 early endosome cellular_component
GO:0005788 endoplasmic reticulum lumen cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005886 plasma membrane cellular_component
GO:0009897 external side of plasma membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0042101 T cell receptor complex cellular_component
GO:0045121 membrane raft cellular_component
GO:0001948 glycoprotein binding molecular_function
GO:0004872 receptor activity molecular_function
GO:0004888 transmembrane signaling receptor activity molecular_function
GO:0005201 extracellular matrix structural constituent molecular_function
GO:0005515 protein binding molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0015026 coreceptor activity molecular_function
GO:0019899 enzyme binding molecular_function
GO:0019901 protein kinase binding molecular_function
GO:0042289 MHC class II protein binding molecular_function
GO:0042803 protein homodimerization activity molecular_function