DAA2547 |
Level of miR-21 decreases with age |
Molecular |
T cell |
Human |
MIR21 |
83.6% Decrease miRNA Level |
|
DAA2560 |
Level of miR-342-3p increases with age |
Molecular |
T cell |
Human |
MIR342 |
57.5% Increase miRNA Level |
|
DAA1231 |
decreased NF-KappaB induction in T cells |
Molecular |
T cell |
Human |
— |
— |
|
DAA2549 |
Level of miR-23a increases with age |
Molecular |
T cell |
Human |
MIR23A |
137.2% Increase miRNA Level |
|
DAA2550 |
Level of miR-519d decreases with age |
Molecular |
T cell |
Human |
MIR519D |
61.6% Decrease miRNA Level |
|
DAA2561 |
Level of let-7i decreases with age |
Molecular |
T cell |
Human |
MIRLET7I |
46.9% Decrease miRNA Level |
|
DAA952 |
Fewer CD4+ and CD8+ cells |
Physiological |
T cell |
Human |
— |
— |
|
DAA2573 |
Level of miR-27b decreases with age |
Molecular |
T cell |
Human |
MIR27B |
31.7% Decrease miRNA Level |
|
DAA2565 |
Level of miR-23b increases with age |
Molecular |
T cell |
Human |
MIR23B |
32.8% Increase miRNA Level |
|
DAA2578 |
Level of miR-15b decreases with age |
Molecular |
T cell |
Human |
MIR15B |
29.4% Decrease miRNA Level |
|
DAA2558 |
Level of miR-27a decreases with age |
Molecular |
T cell |
Human |
MIR27A |
47.7% Decrease miRNA Level |
|
DAA2576 |
Level of miR-98 decreases with age |
Molecular |
T cell |
Human |
MIR98 |
43.8% Decrease miRNA Level |
|
DAA964 |
T-cell diversity declines |
Physiological |
T cell |
Human |
— |
— |
|
DAA953 |
Increase in cells that are both CD8+ and CD28-null |
Physiological |
T regulatory cell |
Human |
— |
— |
|
DAA955 |
Interleukin-7 production declines |
Physiological |
stromal cell |
Human |
IL7 |
— |
|
DAA963 |
Expansion into effector cells is reduced |
Physiological |
naïve T cell |
Human |
— |
— |
|
DAA959 |
telomere shortening |
Molecular |
naïve T cell |
Human |
— |
— |
|
DAA977 |
ROS production in response to stimuli unchanged |
Physiological |
neutrophil |
Human |
— |
— |
|
DAA972 |
Chemotaxis and adhesion activity unchanged in vitro |
Physiological |
neutrophil |
Human |
— |
— |
|
DAA982 |
expression of CD16 receptor diminished |
Molecular |
neutrophil |
Human |
FCGR3A |
— |
|
DAA979 |
Apoptotic pathway in response to stimuli disrupted |
Physiological |
neutrophil |
Human |
— |
— |
|
DAA980 |
Phagocytosis activity decreased in response to opsonized targets |
Physiological |
neutrophil |
Human |
— |
— |
|
DAA975 |
Infiltration at injury site is reduced |
Physiological |
neutrophil |
Human |
— |
— |
|
DAA973 |
Chemotaxis and respiratory burst capacity in response to GM-CSF priming decreased |
Physiological |
neutrophil |
Human |
— |
— |
|
DAA974 |
Chemotaxis is reduced |
Physiological |
neutrophil, dendritic cell |
Human |
— |
— |
|