| DAA2058 |
Mosaic abnormalities increase |
Physiological |
blood, oral cavity |
Human |
— |
— |
|
| DAA1218 |
Morning concentrations of oestradiol decline |
Physiological |
plasma |
Human |
— |
— |
|
| DAA1221 |
Morning concentration of sex-hormone binding globulin declines |
Physiological |
plasma |
Human |
— |
— |
|
| DAA1219 |
Morning concentration of oestrone (E1) declines |
Physiological |
plasma |
Human |
— |
— |
|
| DAA2597 |
Mitochondrial DNA content in non-centenerians decreases with age |
Physiological |
blood |
Human |
— |
— |
|
| DAA2014 |
Microsatellite instability in hematopoietic stem cells and progenitor cells |
Physiological |
hematopoietic stem cells |
Human |
MLH1 |
— |
|
| DAA909 |
Mean blood glucose level increases |
Physiological |
plasma |
Human |
— |
— |
|
| DAA925 |
Increase in follicle stimulating hormone (FSH) and luteinizing hormone (LH) preceding menopause |
Physiological |
plasma |
Human |
— |
— |
|
| DAA1207 |
IL8 level increase |
Physiological |
plasma |
Human |
IL8 |
— |
|
| DAA2593 |
Glycosylation of immunoglobulin G molecules changes with age |
Physiological |
blood |
Human |
— |
— |
|
| DAA1215 |
Higher adrenocroticotropic hormone levels |
Physiological |
plasma |
Human |
POMC |
— |
|
| DAA1991 |
Hematopoietic cells accumulate random mutations |
Physiological |
hematopoietic stem cells |
Human |
— |
— |
|
| DAA1073 |
Fewer cells and higher apoptosis |
Physiological |
bone marrow |
Human |
— |
— |
|
| DAA2027 |
DNA damage acummulates in hematopoietic stem and progenitor cells |
Physiological |
hematopoietic stem cells |
Human |
— |
— |
|
| DAA910 |
DHEA levels decrease |
Physiological |
plasma |
Human |
— |
— |
|
| DAA1988 |
Decrease in the 24-hour integrated concentration of GH |
Physiological |
plasma |
Human |
GH1 |
— |
|
| DAA921 |
Decrease in melatonin concentration and loss of circadian rhythm for secretion |
Physiological |
plasma, pineal gland |
Human |
— |
— |
|
| DAA916 |
Cortisol levels increased |
Physiological |
plasma |
Human |
— |
— |
|
| DAA1214 |
Circadian prolactin flattened |
Physiological |
plasma |
Human |
PRL |
— |
|
| DAA1212 |
Circadian plasma melatonin flattened |
Physiological |
plasma |
Human |
— |
— |
|
| DAA1213 |
Circadian GH change |
Physiological |
plasma |
Human |
GH1 |
— |
|
| DAA968 |
Chronic inflammation increases |
Physiological |
blood, immune system |
Human |
— |
— |
|
| DAA678 |
Capacity of mesenchymal stem cells to differentiate into osteoblasts may be decreased |
Physiological |
mesenchymal stem cell |
Human |
— |
— |
|
| DAA2018 |
Blood volume per unit of body weight unchanged |
Physiological |
blood |
Human |
— |
— |
|
| DAA1208 |
Blood TNF-alpha level increase |
Physiological |
plasma |
Human |
TNF |
— |
|