| DAA1996 |
Beta-amyloid protein deposition increases |
Physiological |
brain |
Human |
APP |
— |
|
| DAA1943 |
Motor coordination decreases |
Physiological |
musculoskeletal system, nervous system |
Mouse |
— |
— |
|
| DAA960 |
Receptor expression alterations |
Physiological |
grey matter |
Human |
— |
— |
|
| DAA1941 |
Gait width increases |
Physiological |
nervous system |
Mouse |
— |
— |
|
| DAA2037 |
Decrease in mitochondrial content and oxidative metabolism in cells |
Physiological |
brain |
Mouse |
— |
— |
|
| DAA730 |
White matter volume decreases |
Physiological |
white matter |
Human |
— |
— |
|
| DAA2583 |
Vision loss |
Physiological |
visual apparatus |
Human |
— |
— |
|
| DAA788 |
Viscoelastic modulus of brain tissue decreases |
Physiological |
brain |
Human |
— |
— |
|
| DAA2030 |
Transmission of visible light through eye lenses decreases |
Physiological |
lens |
Human |
— |
— |
|
| DAA718 |
Synaptic density slightly decreases at advanced ages |
Physiological |
frontal lobe |
Human |
— |
— |
|
| DAA2032 |
The ratio of free to bound water increases |
Physiological |
lens |
Human |
— |
— |
|
| DAA743 |
Sensitivity of HPA axis is impaired |
Physiological |
pituitary gland, adrenal gland, hypothalamus |
Human |
— |
— |
|
| DAA1981 |
Selective increase in oxidative damage and decrease in antioxidant function during aging in the substantia nigra |
Physiological |
substantia nigra |
Human |
— |
— |
|
| DAA785 |
Reduced hippocampal activity and functional connectivity in tests for verbal familiarity |
Physiological |
brain |
Human |
— |
— |
|
| DAA1949 |
Intracellular glutathione content decreases |
Physiological |
brain |
Mouse |
— |
— |
|
| DAA1980 |
Reaction time for a visually paced simple motor task increases with age |
Physiological |
brain |
Human |
— |
— |
|
| DAA763 |
Prolongation of calcium signals in nerve cells |
Physiological |
brain |
Human |
— |
— |
|
| DAA1076 |
Progressive liquefaction |
Physiological |
vitreous humor |
Human |
— |
— |
|
| DAA779 |
Prefrontal cortex activation during learning is reduced |
Physiological |
brain |
Human |
— |
— |
|
| DAA737 |
Permeability increases with age |
Physiological |
blood brain barrier |
Human |
— |
— |
|
| DAA757 |
Parkinsonian signs |
Physiological |
nervous system |
Human |
— |
— |
|
| DAA733 |
Neurotransmitter and neuro receptor concentrations are altered |
Physiological |
brain |
Human |
— |
— |
|
| DAA714 |
Neuronal soma shrinks in size |
Physiological |
brain |
Human |
— |
— |
|
| DAA2036 |
Neural stem cell pool declines |
Physiological |
hippocampus |
Mouse |
— |
— |
|
| DAA721 |
Neurofibrillary tangles and Lewy bodies in neurons |
Physiological |
brain |
Human |
— |
— |
|