DAA764 |
Depolarization of mitochondria |
Physiological |
brain |
Human |
— |
— |
|
DAA717 |
Dendrite regression, reduction in dendrite length |
Physiological |
brain |
Human |
— |
— |
|
DAA739 |
Degeneration of dopamine neurons and receptors |
Physiological |
brain |
Human |
— |
— |
|
DAA740 |
Cortical plasticity decreases |
Physiological |
brain |
Human |
— |
— |
|
DAA738 |
Cerebral spinal fluid amount increases |
Physiological |
brain |
Human |
— |
— |
|
DAA741 |
Cerebral blood flow and glucose utilization are reduced |
Physiological |
brain |
Human |
— |
— |
|
DAA765 |
Calcium binding capacity decreases in neurons |
Physiological |
brain |
Human |
— |
— |
|
DAA1993 |
Brain volume decreases in a regional-specific way |
Physiological |
brain |
Human |
— |
— |
|
DAA1217 |
Brain volume decrease |
Physiological |
brain |
Human |
— |
— |
|
DAA728 |
Brain matter volume declines |
Physiological |
brain |
Human |
— |
— |
|
DAA1996 |
Beta-amyloid protein deposition increases |
Physiological |
brain |
Human |
APP |
— |
|
DAA2041 |
Altered brain mitochondrial metabolism |
Physiological |
brain |
Human |
— |
— |
|
DAA723 |
Accumulation of extracellular neuritic plaques |
Physiological |
brain |
Human |
— |
— |
|
DAA785 |
Reduced hippocampal activity and functional connectivity in tests for verbal familiarity |
Physiological |
brain |
Human |
— |
— |
|
DAA1948 |
Neurogenesis is reduced |
Physiological |
brain |
Mouse |
— |
— |
|
DAA724 |
Global neuron loss |
Physiological |
cerebral cortex |
Human |
— |
— |
|
DAA732 |
Glial cell number |
Physiological |
cerebral cortex |
Human |
— |
— |
|
DAA2026 |
Mutations in mitochondrial DNA accumulate |
Physiological |
heart, kidney, skeletal muscle, cerebral cortex, cerebellum |
Human |
— |
— |
|
DAA718 |
Synaptic density slightly decreases at advanced ages |
Physiological |
frontal lobe |
Human |
— |
— |
|
DAA1984 |
Layer-specific dendritic regression of pyramidal cells |
Physiological |
prefrontal cortex |
Human |
— |
— |
|
DAA2036 |
Neural stem cell pool declines |
Physiological |
hippocampus |
Mouse |
— |
— |
|
DAA743 |
Sensitivity of HPA axis is impaired |
Physiological |
pituitary gland, adrenal gland, hypothalamus |
Human |
— |
— |
|
DAA722 |
Accumulation of neuromelanin in dopaminergic nigral neurons |
Physiological |
substantia nigra |
Human |
— |
— |
|
DAA1981 |
Selective increase in oxidative damage and decrease in antioxidant function during aging in the substantia nigra |
Physiological |
substantia nigra |
Human |
— |
— |
|
DAA2026 |
Mutations in mitochondrial DNA accumulate |
Physiological |
heart, kidney, skeletal muscle, cerebral cortex, cerebellum |
Human |
— |
— |
|