All changes for the tissue central nervous system (54)

Identifier Name Type Tissues Organism Gene Data Actions
DAA730 White matter volume decreases Physiological white matter Human — —
DAA729 Gray matter volume decreases Physiological grey matter Human — —
DAA728 Brain matter volume declines Physiological brain Human — —
DAA727 Axon loss Physiological white matter Human — —
DAA726 Demyelination Physiological white matter Human — —
DAA725 Leukoaraiosis Physiological white matter Human — —
DAA724 Global neuron loss Physiological cerebral cortex Human — —
DAA723 Accumulation of extracellular neuritic plaques Physiological brain Human — —
DAA722 Accumulation of neuromelanin in dopaminergic nigral neurons Physiological substantia nigra Human — —
DAA721 Neurofibrillary tangles and Lewy bodies in neurons Physiological brain Human — —
DAA718 Synaptic density slightly decreases at advanced ages Physiological frontal lobe Human — —
DAA717 Dendrite regression, reduction in dendrite length Physiological brain Human — —
DAA715 Lipid biosynthesis decreases Physiological central nervous system Human — —
DAA714 Neuronal soma shrinks in size Physiological brain Human — —
DAA2596 Frequency of mitochondrial DNA deletions increases with age Physiological brain Human — —
DAA2595 Frequency of somatic mitochondrial mutations increases with age Physiological brain Human — —
DAA2041 Altered brain mitochondrial metabolism Physiological brain Human — —
DAA2037 Decrease in mitochondrial content and oxidative metabolism in cells Physiological brain Mouse — —
DAA2036 Neural stem cell pool declines Physiological hippocampus Mouse — —
DAA2026 Mutations in mitochondrial DNA accumulate Physiological heart, kidney, skeletal muscle, cerebral cortex, cerebellum Human — —
DAA2026 Mutations in mitochondrial DNA accumulate Physiological heart, kidney, skeletal muscle, cerebral cortex, cerebellum Human — —
DAA1996 Beta-amyloid protein deposition increases Physiological brain Human APP —
DAA1993 Brain volume decreases in a regional-specific way Physiological brain Human — —
DAA1984 Layer-specific dendritic regression of pyramidal cells Physiological prefrontal cortex Human — —
DAA1981 Selective increase in oxidative damage and decrease in antioxidant function during aging in the substantia nigra Physiological substantia nigra Human — —